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Vitanox: Combat oxidative stress with polyphenols

tue, 1 jul 2014
In highly-productive animals, or during stressful periods (e.g. weaning, heat stress, ...) all cellular metabolic processes in the body are accelerated, including the oxidation processes. This leads to an increased production of free radicals, with harmful effects in the body as a result. For this reason, Nuscience developed Vitanox, with a proven positive effect on oxidative stress within the cell and an improvement in gut integrity through its positive effect on the so-called ‘tight junctions’.

The balance between oxidation and antioxidation is of crucial importance in the maintenance of cell integrity and health. If the equilibrium shifts to a high level of oxidation and the production of free radicals exceeds the body’s capacity to neutralise these highly reactive compounds, oxidative stress occurs.

Animal feeds are traditionally supplemented with antioxidative compounds, such as vitamin E and selenium, to combat the problems of oxidative stress. Vegetable-based polyphenols, a varied group of more than 8,000 different compounds, are also known for their powerful antioxidative properties. The majority of studies with vegetable polyphenols are however only based on ORAC values. The findings from these chemical tests cannot always be verified in biological systems.

In the development of Vitanox, Nuscience clearly went a step further than the standard determination of ORAC (Oxygen Radical Absorbance Capacity) values. In a series of experiments with a monolayer of epithelial cells (a Boyden chamber), different active components were screened for their effect on the oxidative status within the cells. Effects on gut integrity could also be demonstrated resulting in a reduced susceptibility to toxins, bacteria, antigens etc. In this test, the composition of Vitanox excelled even the function of vitamin E.

Vitanox is therefore a valuable functional feed ingredient to combat oxidative stress, resulting in improved performance of the animals. Through a sparing effect on vitamin E, it is moreover economically interesting!